We also uncover unexpected phylogenetic differences in scgn expression, since this CBP is restricted to primate cholinergic basal forebrain neurons.

Overall, we characterize scgn as a neuron-specific CBP whose distribution identifies neuronal subtypes and hierarchical organizing principles in the mammalian brain.

What happens when the group includes children who become attached to adults, and those beloved adults are the ones who leave?

The adult mouse brain contains two main neurogenic niches, in which NSCs continually divide to give rise to new neurons: the subgranular zone of the dentate gyrus (DG) and the SVZ lining the lateral ventricles (boxed areas).

In the SVZ, astrocytic cells with stem cell properties, called type B cells, divide to give rise to fast-proliferating, transit-amplifying cells (type C cells) that in turn generate neuroblasts migrating along the rostral migratory stream (RMS) toward the olfactory bulb, where they integrate into the existing neural circuitry.

Although subtle phylogenetic variations in the neuronal distribution of these CBPs may occur, morphologically and functionally diverse subclasses of interneurons harbor these proteins in olfactory and corticolimbic areas.

Secretagogin (scgn) is a recently cloned CBP from pancreatic β and neuroendocrine cells.